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Literature summary for 3.4.21.92 extracted from

  • Boettcher, T.; Sieber, S.A.
    Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus (2008), J. Am. Chem. Soc., 130, 14400-14401.
    View publication on PubMed
Search for more literature for 3.4.21.92

Application

Application Comment Organism
drug development synthetic beta-lactones as novel inhibitors for specific and selective targeting of the key virulence regulator ClpP Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Staphylococcus aureus
3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one exerts the weakest effect on peptidase activity Staphylococcus aureus
3-butyl-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
ClpP
-
 Staphylococcus aureus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
 3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus
0.006
-
 3-butyl-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus
0.031
-
 3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus