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Literature summary for 3.4.21.92 extracted from
- ClpP: a distinctive family of cylindrical energy-dependent serine proteases (2007), FEBS Lett., 581, 3749-3757.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| acyldepsipeptide | allow the protease to degrade folded native proteins in the absence of its cognate chaperones | Escherichia coli |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ClpP as antibacterial drug target | Escherichia coli |
| medicine | ClpP as antibacterial drug target | Streptococcus pneumoniae |
| medicine | ClpP as antibacterial drug target | Mycobacterium tuberculosis |
| medicine | ClpP as antibacterial drug target | Plasmodium falciparum |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| ClpP structures have been solved from five different organisms | Escherichia coli |
| ClpP structures have been solved from five different organisms | Streptococcus pneumoniae |
| ClpP structures have been solved from five different organisms | Mycobacterium tuberculosis |
| ClpP structures have been solved from five different organisms | Plasmodium falciparum |
| ClpP structures have been solved from five different organisms, human ClpP can form a complex with Escherichia coli ClpX in vitro | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 300000 | - |
- |
Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Plasmodium falciparum | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heptamer | - |
Homo sapiens |
| tetradecamer | - |
Escherichia coli |
| tetradecamer | - |
Streptococcus pneumoniae |
| tetradecamer | - |
Mycobacterium tuberculosis |
| tetradecamer | - |
Plasmodium falciparum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Clp protease | - |
Escherichia coli |
| Clp protease | - |
Homo sapiens |
| Clp protease | - |
Streptococcus pneumoniae |
| Clp protease | - |
Mycobacterium tuberculosis |
| Clp protease | - |
Plasmodium falciparum |
| Clp proteolytic subunit | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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