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Literature summary for 3.4.21.91 extracted from
- Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects (1999), J. Biol. Chem., 274, 5573-5580.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NS2B | viral activator protein | Dengue virus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure at 2.1 A resolution | Dengue virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D129E | no significant loss of activity | Dengue virus |
| D129L | no significant loss of activity | Dengue virus |
| D129R | no significant loss of activity | Dengue virus |
| D129S | no significant loss of activity | Dengue virus |
| additional information | mutation at G153 results in inactivation | Dengue virus |
| S135A | almost inactive | Dengue virus |
| S135C | almost inactive | Dengue virus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dengue virus | - |
- |
- |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | heterodimer of NS3 and NS2B, i.e. serine protease and viral activator protein resp. | Dengue virus |
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