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Literature summary for 3.4.21.91 extracted from

  • Lei, J.; Hansen, G.; Nitsche, C.; Klein, C.D.; Zhang, L.; Hilgenfeld, R.
    Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor (2016), Science, 353, 503-505 .
    View publication on PubMed
Search for more literature for 3.4.21.91

Crystallization (Commentary)

Crystallization (Comment) Organism
purified ZIKV protease in complex with a peptidomimetic boronic acid inhibitor, X-ray diffraction structure determination and analysis at 2.7 A resolution Zika virus

Inhibitors

Inhibitors Comment Organism Structure
4-(aminomethyl)-Nalpha-benzoyl-N-[(1R)-4-carbamimidamido-1-(dihydroxyboranyl)butyl]-L-phenylalaninamide cn-716, ZIKV protease in complex with a peptidomimetic boronic acid inhibitor reveals a cyclic diester between the boronic acid and glycerol, enzyme binding structure, binds to the active site, crystal structure analysis, detailed overview Zika virus

Organism

Organism UniProt Comment Textmining
Zika virus A0A140DLX4 ZIKV
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Zika virus Brazilian isolate BeH823339 A0A140DLX4 ZIKV
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-norleucyl-lysyl-lysyl-argininyl-7-amido-4-methylcoumarin + H2O
-
 Zika virus benzoyl-norleucyl-lysyl-lysyl-arginine + 7-amino-4-methylcoumarin
-
 ?
benzoyl-norleucyl-lysyl-lysyl-argininyl-7-amido-4-methylcoumarin + H2O
-
 Zika virus Brazilian isolate BeH823339 benzoyl-norleucyl-lysyl-lysyl-arginine + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
NS2B-NS3 protease
-
 Zika virus

General Information

General Information Comment Organism
physiological function the Zika virus (ZIKV) relies on its NS2B/NS3 protease for polyprotein processing Zika virus