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Literature summary for 3.4.21.91 extracted from

  • Kouretova, J.; Hammamy, M.Z.; Epp, A.; Hardes, K.; Kallis, S.; Zhang, L.; Hilgenfeld, R.; Bartenschlager, R.; Steinmetzer, T.
    Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication (2017), J. Enzyme Inhib. Med. Chem., 32, 712-721 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.91

Inhibitors

Inhibitors Comment Organism Structure
(2S)-4-[3-(aminomethyl)phenyl]-2-([(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide 5.5% inhibition Dengue virus
(2S)-4-[3-(aminomethyl)phenyl]-2-([(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide
-
 West Nile virus
(2S)-4-[4-(aminomethyl)phenyl]-2-([(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide 10.8% inhibition Dengue virus
(2S)-4-[4-(aminomethyl)phenyl]-2-([(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide
-
 West Nile virus
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[3-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide
-
 Dengue virus
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[3-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide
-
 West Nile virus
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[4-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide 17.1% inhibition Dengue virus
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[4-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide
-
 West Nile virus
4-(guanidinomethyl)-phenylacetyl-Lys-Lys-Arg-NH2
-
 Dengue virus
4-(guanidinomethyl)-phenylacetyl-Lys-Lys-Arg-NH2
-
 West Nile virus
additional information inhibitor screening, a strong inhibitory potency is found for simple phenylacetyl-capped tripeptides containing a C-terminal P1 arginyl amide moiety and for their elongated derivatives with one or two glycine residues in the P1' and P2' positions. Inhibitory potencies of synthesized compounds, comparison to human furin, and West nile virus, structure-activity relationships, overview Dengue virus
additional information inhibitor screening, a strong inhibitory potency is found for simple phenylacetyl-capped tripeptides containing a C-terminal P1 arginyl amide moiety and for their elongated derivatives with one or two glycine residues in the P1' and P2' positions. The compounds seem to be poor substrates of the WNV NS2BNS3 protease and therefore, act as competitive inhibitors. Inhibitory potencies of synthesized compounds, comparison to human furin, and West nile virus, structure-activity relationships, overview West Nile virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-(4-carbamimidamidophenyl)-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide 14.7% inhibition Dengue virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-(4-carbamimidamidophenyl)-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 West Nile virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[3-(carbamimidamidomethyl)cyclohexa-1,5-dien-1-yl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 Dengue virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[3-(carbamimidamidomethyl)cyclohexa-1,5-dien-1-yl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 West Nile virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[4-(carbamimidamidomethyl)phenyl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 Dengue virus
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[4-(carbamimidamidomethyl)phenyl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 West Nile virus
N-[(2S)-4-[3-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 Dengue virus
N-[(2S)-4-[3-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
 West Nile virus
N-[(2S)-4-[4-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-ornithinamide
-
 Dengue virus
N-[(2S)-4-[4-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-ornithinamide
-
 West Nile virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-(3-carbamimidamidophenyl)-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
 Dengue virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-(3-carbamimidamidophenyl)-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
 West Nile virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide 31.1% inhibition Dengue virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
 West Nile virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
 Dengue virus
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
 West Nile virus
N2-(1,3-benzodioxol-5-ylacetyl)-L-lysyl-L-lysinamide 19.9% inhibition Dengue virus
N2-(1,3-benzodioxol-5-ylacetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(adamant-1-yl(amino)acetyl)-L-lysyl-L-lysinamide 14.6% inhibition Dengue virus
N2-(adamant-1-yl(amino)acetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(adamant-1-ylacetyl)-L-lysyl-L-lysinamide 24.2% inhibition Dengue virus
N2-(adamant-1-ylacetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(biphenyl-4-ylacetyl)-L-lysyl-L-lysinamide 27.1% inhibition Dengue virus
N2-(biphenyl-4-ylacetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(cyclohexylacetyl)-L-lysyl-L-lysinamide 31.7% inhibition; 36.7% inhibition Dengue virus
N2-(cyclohexylacetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysinamide 20.8% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysine
-
 Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysine
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-3-methylvalinamide 6.4% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-3-methylvalinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-D-alaninamide 12.0% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-D-alaninamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-alaninamide 5.6% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-alaninamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-prolinamide 5.2% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-prolinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-valinamide 12.0% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-valinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-N2-methylglycinamide 3.2% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysyl-N2-methylglycinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-L-lysylglycinamide 30.7% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-L-lysylglycinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-N-(2-aminoprop-2-en-1-yl)-L-lysinamide 35.1% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-N-(2-aminoprop-2-en-1-yl)-L-lysinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-N-(4-amino-4-oxobutyl)-L-lysinamide 26.3% inhibition Dengue virus
N2-(phenylacetyl)-L-lysyl-N-(4-amino-4-oxobutyl)-L-lysinamide
-
 West Nile virus
N2-(phenylacetyl)-L-lysyl-N-(5-amino-5-oxopentyl)-L-lysinamide
-
 Dengue virus
N2-(phenylacetyl)-L-lysyl-N-(5-amino-5-oxopentyl)-L-lysinamide
-
 West Nile virus
N2-(phenylacetyl)-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 Dengue virus
N2-(phenylacetyl)-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 West Nile virus
N2-[(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 Dengue virus
N2-[(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 West Nile virus
N2-[(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide 12.4% inhibition Dengue virus
N2-[(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 West Nile virus
N2-[(3,4-dichlorophenyl)acetyl]-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
 West Nile virus
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysinamide 25.1% inhibition Dengue virus
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysylglycinamide 45.0% inhibition Dengue virus
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysylglycinamide
-
 West Nile virus
N2-[(3-aminophenyl)acetyl]-L-lysyl-L-lysinamide 27.5% inhibition Dengue virus
N2-[(3-aminophenyl)acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[(4-hydroxyphenyl)acetyl]-L-lysyl-L-lysinamide 27.5% inhibition Dengue virus
N2-[(4-hydroxyphenyl)acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[(acetylamino)(phenyl)acetyl]-L-lysyl-L-lysinamide
-
 Dengue virus
N2-[(acetylamino)(phenyl)acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[amino(phenyl)acetyl]-L-lysyl-L-lysinamide
-
 Dengue virus
N2-[amino(phenyl)acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[[3-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide 12.4% inhibition Dengue virus
N2-[[3-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[[3-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide 32.3% inhibition Dengue virus
N2-[[3-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[[4-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide 31.7% inhibition Dengue virus
N2-[[4-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 Dengue virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 West Nile virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-arginyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 Dengue virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-arginyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 West Nile virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-lysyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 Dengue virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-lysyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 West Nile virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 Dengue virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
-
 West Nile virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide 65.0% inhibition Dengue virus
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
 West Nile virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0475
-
 phenylacetyl-Lys-Lys-Arg-4-nitroanilide pH 8.5, 22°C West Nile virus
0.06
-
 phenylacetyl-Lys-Lys-Arg-4-nitroanilide pH 8.5, 22°C Dengue virus

Organism

Organism UniProt Comment Textmining
Dengue virus
-
 DENV
-
West Nile virus
-
 WNV
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phenylacetyl-Lys-Lys-Arg-4-nitroanilide + H2O
-
 Dengue virus phenylacetyl-Lys-Lys-Arg + 4-nitroaniline
-
 ?
phenylacetyl-Lys-Lys-Arg-4-nitroanilide + H2O chromogenic substrate West Nile virus phenylacetyl-Lys-Lys-Arg + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
DENV NS2B-NS3
-
 Dengue virus
NS2B-NS3 protease
-
 Dengue virus
NS2B-NS3 protease
-
 West Nile virus
WNV NS2B-NS3
-
 West Nile virus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Dengue virus
22
-
 assay at room temperature West Nile virus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Dengue virus
8.5
-
 assay at West Nile virus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00011
-
 N2-[(3,4-dichlorophenyl)acetyl]-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.00011
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00011
-
 4-(guanidinomethyl)-phenylacetyl-Lys-Lys-Arg-NH2 pH 8.5, 22°C West Nile virus
0.00018
-
 N2-[[3-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00036
-
 N2-[[3-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00038
-
 N2-[[4-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00053
-
 N2-(biphenyl-4-ylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00054
-
 N2-[(4-hydroxyphenyl)acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00065
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-arginyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C West Nile virus
0.00068
-
 N2-(1,3-benzodioxol-5-ylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00082
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-lysyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C West Nile virus
0.00113
-
 N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.0012
-
 N2-(phenylacetyl)-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.0012
-
 N2-[(3-aminophenyl)acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00122
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-lysyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C Dengue virus
0.00156
-
 N2-(phenylacetyl)-L-lysyl-N-(2-aminoprop-2-en-1-yl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.0018
-
 N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysylglycinamide pH 8.5, 22°C West Nile virus
0.00247
-
 N2-(phenylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00256
-
 N2-(phenylacetyl)-L-lysyl-L-lysylglycinamide pH 8.5, 22°C West Nile virus
0.0036
-
 N2-[amino(phenyl)acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00418
-
 N2-[(acetylamino)(phenyl)acetyl]-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.00471
-
 N2-[(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.0048
-
 N2-(cyclohexylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.0057
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C West Nile virus
0.00645
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C West Nile virus
0.0116
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-arginyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C Dengue virus
0.0136
-
 (2S)-4-[4-(aminomethyl)phenyl]-2-([(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide pH 8.5, 22°C West Nile virus
0.0138
-
 N2-(adamant-1-ylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.015
-
 N2-(phenylacetyl)-L-lysyl-N-(4-amino-4-oxobutyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.017
-
 N2-(phenylacetyl)-L-lysyl-N-(5-amino-5-oxopentyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.0182
-
 N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-(4-carbamimidamidophenyl)-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.0216
-
 (2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[3-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide pH 8.5, 22°C West Nile virus
0.0222
-
 N2-[(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.025
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-L-alaninamide pH 8.5, 22°C West Nile virus
0.0263
-
 N2-(cyclohexylacetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.027
-
 N2-(phenylacetyl)-L-lysyl-L-lysine pH 8.5, 22°C West Nile virus
0.0289
-
 N-[(2S)-4-[4-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-ornithinamide pH 8.5, 22°C West Nile virus
0.0296
-
 N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.0298
-
 N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-(3-carbamimidamidophenyl)-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.044
-
 N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide pH 8.5, 22°C West Nile virus
0.0442
-
 (2S)-4-[3-(aminomethyl)phenyl]-2-([(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide pH 8.5, 22°C West Nile virus
0.05
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-N2-methylglycinamide pH 8.5, 22°C West Nile virus
0.07
-
 N2-(adamant-1-yl(amino)acetyl)-L-lysyl-L-lysinamide pH 8.5, 22°C West Nile virus
0.075
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-D-alaninamide pH 8.5, 22°C West Nile virus
0.0756
-
 N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[4-(carbamimidamidomethyl)phenyl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.0773
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C Dengue virus
0.0831
-
 N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide pH 8.5, 22°C Dengue virus
0.0853
-
 (2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[4-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide pH 8.5, 22°C West Nile virus
0.0994
-
 N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[3-(carbamimidamidomethyl)cyclohexa-1,5-dien-1-yl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.105
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-L-valinamide pH 8.5, 22°C West Nile virus
0.134
-
 N-[(2S)-4-[3-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide pH 8.5, 22°C West Nile virus
0.14
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-3-methylvalinamide pH 8.5, 22°C West Nile virus
0.2
-
 N2-(phenylacetyl)-L-lysyl-L-lysyl-L-prolinamide pH 8.5, 22°C West Nile virus
5.5
-
 (2S)-4-[3-(aminomethyl)phenyl]-2-([(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide pH 8.5, 22°C Dengue virus
10.8
-
 (2S)-4-[4-(aminomethyl)phenyl]-2-([(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide pH 8.5, 22°C Dengue virus
12.4
-
 N2-[(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide pH 8.5, 22°C Dengue virus
14.7
-
 N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-(4-carbamimidamidophenyl)-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide pH 8.5, 22°C Dengue virus
17.1
-
 (2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[4-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide pH 8.5, 22°C Dengue virus
31.1
-
 N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide pH 8.5, 22°C Dengue virus