Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R,7aS)-2,3-bis(4-nitrophenyl)hexahydro-1H-pyrrolo-[1,2-c]imidazol-1-one | crystal structure analysis | Dengue virus type 2 | |
(3R,7aS)-2-(4-nitrophenyl)-3-(4-(trifluoromethyl)-phenyl)-hexahydro-1H- pyrrolo[1,2-c]-imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3R,7aS)-2-(4-nitrophenyl)-3-phenylhexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | 67% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-(3-nitrophenyl)-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-(4-chlorophenyl)-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]-imidazol-1-one | below 50% inhibition, crystal structure analysis | Dengue virus type 2 | |
(3R,7aS)-3-(4-isopropylphenyl)-2-(4-nitrophenyl)-hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-(4-methoxyphenyl)-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-(4-nitrobenzyl)-2-(4-nitrophenyl)hexahydro-1Hpyrrolo[1,2-c]-imidaz-ol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-benzyl-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | 42% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-ethyl-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | 60% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-isopropyl-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | 34% inhibition | Dengue virus type 2 | |
(3R,7aS)-3-methyl-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imidazol-1-one | 42% inhibition | Dengue virus type 2 | |
(3S,7aS)-2,3-bis(4-nitrophenyl)hexahydro-1H-pyrrolo-[1,2-c]imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3S,7aS)-2-(4-nitrophenyl)-3-(4-(trifluoromethyl)-phenyl)hexahydro-1H- pyrrolo[1,2-c]-imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(3S,7aS)-3-(4-chlorophenyl)-2-(4-nitrophenyl)hexa-hydro-1H-pyrrolo[1,2-c]imidazol-1-one | below 50% inhibition | Dengue virus type 2 | |
(S)-2-(4-nitrophenyl)hexahydro-1H-pyrrolo[1,2-c]imida-zol-1-one | 39% inhibition | Dengue virus type 2 | |
D-methionyl-N-(4-nitrobenzyl)-L-prolinamide | 64% inhibition | Dengue virus type 2 | |
D-methionyl-N-benzyl-L-prolinamide | 42% inhibition | Dengue virus type 2 | |
D-methionyl-N-phenyl-L-prolinamide | below 50% inhibition | Dengue virus type 2 | |
L-methionyl-N-(4-nitrophenyl)-L-prolinamide | 68% inhibition | Dengue virus type 2 | |
additional information | identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors. The preliminary structure-activity relationship reveals that a substituent and its stereochemistry at C-3 position, substitution (X) at N-2 arene and a linker (Y) between C-3 position and its attached arene are important for the fused-ring scaffold of pyrrolidino [1,2-c]imidazolidinone to block the active site of NS2B-NS3 protease. The linear dipeptide L-methionyl-N-(4-nitrophenyl)-L-prolinamide) and the non-peptidic fused ring L-methionyl-N-(4-nitrophenyl)-L-prolinamide) show comparable activities against DENV-2 NS2B-NS3 protease and wild-type DENV-2 virus in a viral replication assay | Dengue virus type 2 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dengue virus type 2 | - |
DENV-2 | - |
Synonyms | Comment | Organism |
---|---|---|
DENV-2 NS2B-NS3 protease | - |
Dengue virus type 2 |
NS2B-NS3 protease | - |
Dengue virus type 2 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
pH and temperature not specified in the publication | Dengue virus type 2 | (3R,7aS)-2,3-bis(4-nitrophenyl)hexahydro-1H-pyrrolo-[1,2-c]imidazol-1-one | |
0.0012 | - |
pH and temperature not specified in the publication | Dengue virus type 2 | L-methionyl-N-(4-nitrophenyl)-L-prolinamide |