Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Dengue virus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0062 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.0066 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.011 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.012 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.012 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.013 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.034 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.046 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.053 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.071 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.076 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.12 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.125 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.15 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.18 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.202 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.22 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.36 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
6 | - |
benzoyl-Nle-Lys-Arg-Arg-thiobenzylester | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
7.3 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
8.6 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
8.6 | - |
benzoyl-Nle-Lys-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
52 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
72 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
180 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
210 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dengue virus | - |
serotype 3 | - |
Dengue virus | - |
serotype 1 | - |
Dengue virus | - |
serotype 2 | - |
Dengue virus | - |
serotype 4 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-Nle-Lys-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Dengue virus | benzoyl-Nle-Lys-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O | - |
Dengue virus | benzoyl-Nle-Lys-Arg-Arg + 7-amino-3-carbamoylmethyl-4-methylcoumarin | - |
? | |
benzoyl-Nle-Lys-Arg-Arg-thiobenzylester + H2O | - |
Dengue virus | benzoyl-Nle-Lys-Arg-Arg + thiobenzoic acid | - |
? | |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O | - |
Dengue virus | benzoyl-Nle-Lys-Thr-Arg + 7-amino-3-carbamoylmethyl-4-methylcoumarin | - |
? | |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O | - |
Dengue virus | benzoyl-Nle-Thr-Arg-Arg + 7-amino-3-carbamoylmethyl-4-methylcoumarin | - |
? | |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O | - |
Dengue virus | benzoyl-Thr-Lys-Arg-Arg + 7-amino-3-carbamoylmethyl-4-methylcoumarin | - |
? | |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O | - |
Dengue virus | benzoyl-Thr-Thr-Arg-Arg + 7-amino-3-carbamoylmethyl-4-methylcoumarin | - |
? | |
additional information | strong preference for basic amino acid residues (Arg/Lys) at the P1 position, preference for the P2-4 sites are in the order of Arg > Thr > Gln/Asn/Lys for P2, Lys > Arg > Asn for P3, and Nle > Leu > Lys > Xaa for P4. The prime site substrate specificity is for small and polar amino acids in P1' and P3' | Dengue virus | ? | - |
? | |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Dengue virus | tert-butoxycarbonyl-Gly-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS2B/NS3 | - |
Dengue virus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.05 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.07 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
0.09 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.1 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.13 | - |
tert-butoxycarbonyl-Gly-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.17 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.2 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.21 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.28 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.32 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
0.33 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.43 | - |
benzoyl-Thr-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
0.48 | - |
benzoyl-Thr-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
0.58 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.61 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
0.76 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
0.97 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 1 | Dengue virus | |
1.1 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 3 | Dengue virus | |
1.1 | - |
benzoyl-Nle-Thr-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
1.4 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
1.4 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 2 | Dengue virus | |
2.8 | - |
benzoyl-Nle-Lys-Arg-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
2.9 | - |
benzoyl-Nle-Lys-Arg-Arg-4-methylcoumarin 7-amide | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
4.9 | - |
benzoyl-Nle-Lys-Thr-Arg-7-amido-3-carbamoylmethyl-4-methylcoumarin | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus | |
300 | - |
benzoyl-Nle-Lys-Arg-Arg-thiobenzylester | pH 8.5, 37°C, enzyme from Dengue virus serotype 4 | Dengue virus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000079 | - |
Aprotinin | enzyme from Dengue virus serotype 1 | Dengue virus |