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Literature summary for 3.4.21.91 extracted from
- Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease (1992), J. Virol., 66, 1535-1542.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Dengue virus DEN4 polyprotein | Dengue virus |
| using recombinant vaccinia virus expression system | Dengue virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Dengue virus DEN4 polyprotein + H2O | Dengue virus | involved in processing of downstream nonstructural proteins of the Dengue virus DEN4 polyprotein precursor | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dengue virus | - |
i.e. DEN4 (and recombinant forms) | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Dengue virus DEN4 polyprotein + H2O | involved in processing of downstream nonstructural proteins of the Dengue virus DEN4 polyprotein precursor | Dengue virus | ? | - |
? | |
| Dengue virus polyprotein + H2O | cleaves NS3/NS4A and NS4B/NS5 junctions, not NS4A/4B junction, cleavage site consists of 2 basic amino acids followed by Gly, Ala or Ser, e.g. Arg-Arg-/-Gly | Dengue virus | Dengue virus proteins NS3 and NS5 | - |
? | |
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