Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antipain | - |
Sus scrofa | |
Aprotinin | - |
Sus scrofa | |
benzamidine | - |
Sus scrofa | |
diisopropylphosphorofluoridate | - |
Sus scrofa | |
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.12 | - |
Gly-Asp-ASp-Asp-Asp-2-naphthylamide | - |
Sus scrofa | |
1.24 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound | Sus scrofa | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CoCl2 | activates | Sus scrofa | |
HgCl2 | activates | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Trypsinogen + H2O | Sus scrofa | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | glycosylated mainly with N-linked carbohydrate chains of the triantennary and tetraantennary complex type | Sus scrofa |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
duodenum | mucosa | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl 7-amide + H2O | - |
Sus scrofa | ? | - |
? | |
Gly-Asp-ASp-Asp-Asp-2-naphthylamide + H2O | - |
Sus scrofa | Gly-Asp-ASp-Asp-Asp + 2-naphthylamine | - |
? | |
Gly-Asp-Asp-Asp-Asp-Lys-2-naphthylamide + H2O | - |
Sus scrofa | Gly-Asp-Asp-Asp-Asp-Lys + 2-naphthylamine | - |
? | |
Lys-2-naphthylamide + H2O | - |
Sus scrofa | Lys + 2-naphthylamine | - |
? | |
additional information | acidic residues at the P2, P3 and/or P4 position are especially favorable for maximal activity, but are not absolutely necessary | Sus scrofa | ? | - |
? | |
tert-butoxycarbonyl-Gln-Ala-Arg-4-methylcoumarin 7-amide + H2O | weak activity | Sus scrofa | ? | - |
? | |
tert-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumaryl 7-amide + H2O | - |
Sus scrofa | ? | - |
? | |
tert-butoxycarbonyl-Leu-Thr-Arg-4-methylcoumarin 7-amide + H2O | weak activity | Sus scrofa | ? | - |
? | |
tert-butoxycarbonyl-Phe-Ser-Arg-4-methylcoumarin 7-amide + H2O | weak activity | Sus scrofa | ? | - |
? | |
tert-butoxycarbonyl-Val-Leu-Lys-4-methylcoumarin 7-amide + H2O | weak activity | Sus scrofa | ? | - |
? | |
Trypsinogen + H2O | - |
Sus scrofa | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
262 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Sus scrofa | |
520 | - |
Gly-Asp-ASp-Asp-Asp-2-naphthylamide | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
hydrolysis of Gly-Asp-Asp-Asp-Asp-Lys-2-naphthylamide | Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.4 | 9 | 50% of maximal activity at pH 6.4 and at pH 9.0, hydrolysis of Gly-Asp-Asp-Asp-Asp-Lys-2-naphthylamide | Sus scrofa |