Application | Comment | Organism |
---|---|---|
medicine | human TRAIL is a candidate for clinical application in cancer therapy, activity is lost in some forms of recombinant TRAIL, refolding of thioredoxin/TRAIL and cleavage by enteropeptidase yield a biological active anticancer agent | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin-tumor necrosis factor-related apoptosis-inducing ligand fusion protein + H2O | trx/TRAIL | Homo sapiens | thioredoxin + tumor necrosis factor-related apoptosis-inducing ligand | enteropeptidase is used to cleave TRAIL from thioredoxin at enzyme-substrate molar ratio of 1 : 30,000 | ? |
Synonyms | Comment | Organism |
---|---|---|
enteropeptidase | - |
Homo sapiens |
enteropeptidase light chain | L-HEP | Homo sapiens |