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Literature summary for 3.4.21.89 extracted from

  • Hazenbos, W.L.; Skippington, E.; Tan, M.W.
    Staphylococcus aureus type I signal peptidase essential or not essential, thats the question (2017), Microb. Cell, 4, 108-111 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.89

Protein Variants

Protein Variants Comment Organism
additional information generation of Staphylococcus aureus bacteria lacking the SPase I SpsB, KIM6+ phoP knockout strain Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane integrative membrane protein Staphylococcus aureus
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-

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus P0A070
-
-

Synonyms

Synonyms Comment Organism
Spase I
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 Staphylococcus aureus
SpsB
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 Staphylococcus aureus
type I signal peptidase
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 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction Staphylococcus aureus bacteria lacking the SPase I SpsB are viable and able to grow in vitro when overexpressing a native gene cassette encoding for a putative ABC transporter. This transporter apparently compensates for SpsB's essential function by mediating alternative cleavage of a subset of proteins at a site distinct from the SpsB-cleavage site, leading to SpsB-independent secretion Staphylococcus aureus
physiological function type I signal peptidase (SPase I) mediates the final step of bacterial secretion, by cleaving proteins at their signal peptide once they are translocated by the Sec or twin-arginine (Tat) translocon. SPase I is important for viability in multiple bacterial pathogens. SpsB cleavage of the signal (or leader) peptide allows protein release from the membrane. A potential distinct secretion system involving an ABC transporter in Staphylococcus aureus is able to bypass the nominal essentiality of SpsB, overview Staphylococcus aureus