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Literature summary for 3.4.21.89 extracted from

  • Midorikawa, T.; Endow, J.K.; Dufour, J.; Zhu, J.; Inoue, K.
    Plastidic type I signal peptidase 1 is a redox-dependent thylakoidal processing peptidase (2014), Plant J., 80, 592-603.
    View publication on PubMed
Search for more literature for 3.4.21.89

Protein Variants

Protein Variants Comment Organism
additional information construction of a N-terminally truncated enzyme lacking amino acids 1-134 and a full-length mature form containing the trans-membrane domain but lacking the transit peptide. N-terminally truncated variant shows very poor activity with PsbO substrate Arabidopsis thaliana
S142A very poor activity with PsbO substrate Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
arylomycin A2 0.01 mM, 90% inhibition Arabidopsis thaliana
dithiothreitol 90% inhibition. Enzyme contains a redox-active Cys pair and requires disulfide bond formation between them for its activity in vitro Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast isoform Plsp1 is the main thylakoidal processing peptidase in Arabidopsis thaliana Arabidopsis thaliana 9507
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8H0W1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
envelope protein Toc75 precursor + H2O
-
 Arabidopsis thaliana mature envelope protein Toc75 + signal peptide
-
 ?
PsbO precursor protein + H2O Zea mays oxygen-evolving enhancer protein 3-1, chloroplastic. Activity is reduced below 10% in Pbs mutant A83L Arabidopsis thaliana mature PcpO + signal peptide
-
 ?

Synonyms

Synonyms Comment Organism
thylakoidal processing peptidase
-
 Arabidopsis thaliana
TPP
-
 Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
 Arabidopsis thaliana