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Literature summary for 3.4.21.89 extracted from

  • Peng, S.B.; Wang, L.; Moomaw, J.; Peery, R.B.; Sun, P.M.; Johnson, R.B.; Lu, J.; Treadway, P
    Skatrud, P.L.; Wang, Q.M.: Biochemical characterization of signal peptidase I from gram-positive Streptococcus pneumoniae (2001), J. Bacteriol., 183, 621-627.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.89

Activating Compound

Activating Compound Comment Organism Structure
Phospholipids stimulates enzymatic activity Streptococcus pneumoniae

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptococcus pneumoniae

Protein Variants

Protein Variants Comment Organism
K76A signal peptidase I, site-directed mutagenesis Streptococcus pneumoniae
S38A signal peptidase I, site-directed mutagenesis Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
signal peptides from preproteins + H2O Streptococcus pneumoniae
-
 mature proteins
-
 ?
streptokinase precursor + H2O Streptococcus pneumoniae extracellular protein, produced in pathogenic streptococci streptokinase
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information precursor of beta-lactamase and pre-OmpA fusion protein are no substrates, incubation at 37°C results in self-cleavage and appearance of 2 products with molecular masses of 19 kDa and 8 kDa Streptococcus pneumoniae ?
-
 ?
signal peptides from preproteins + H2O
-
 Streptococcus pneumoniae mature proteins
-
 ?
streptokinase precursor + H2O extracellular protein, produced in pathogenic streptococci Streptococcus pneumoniae streptokinase
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 incubation at 37°C results in self-cleavage and appearance of 2 products with molecular masses of 19 kDa and 8 kDa, signal peptidase I basically loses its activity after self-cleavage Streptococcus pneumoniae