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Literature summary for 3.4.21.88 extracted from

  • Kumar, A.; Kirti, A.; Rajaram, H.
    LexA protein of cyanobacterium Anabaena sp. strain PCC7120 exhibits in vitro pH-dependent and RecA-independent autoproteolytic activity (2015), Int. J. Biochem. Cell Biol., 59, 84-93.
    View publication on PubMed
Search for more literature for 3.4.21.88

Organism

Organism UniProt Comment Textmining
Anabaena sp. Q8YMM5
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Anabaena sp. PCC 7120 Q8YMM5
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification repressor LexA exhibits a RecA-independent and alkaline pH-dependent autoproteolytic cleavage. The autoproteolytic cleavage occurs at pH 8.5 and above, is stimulated by the addition of Ca2+ and in the temperature range of 30–57°C. The cleavage occurs at the peptide bond between Ala84 and Gly85, and optimal cleavage requires the presence of Ser118and Lys159. Cleavage of Anabaena LexA is affected upon deletion of three amino acids, G86L87I88 Anabaena sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information repressor LexA exhibits a RecA-independent and alkaline pH-dependent autoproteolytic cleavage. The autoproteolytic cleavage occurs at pH 8.5 and above, is stimulated by the addition of Ca2+ and in the temperature range of 30–57°C. The cleavage occurs at the peptide bond between Ala84 and Gly85, and optimal cleavage requires the presence of Ser118and Lys159. Cleavage of Anabaena LexA is affected upon deletion of three amino acids, G86L87I88 Anabaena sp. ?
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 ?
additional information repressor LexA exhibits a RecA-independent and alkaline pH-dependent autoproteolytic cleavage. The autoproteolytic cleavage occurs at pH 8.5 and above, is stimulated by the addition of Ca2+ and in the temperature range of 30–57°C. The cleavage occurs at the peptide bond between Ala84 and Gly85, and optimal cleavage requires the presence of Ser118and Lys159. Cleavage of Anabaena LexA is affected upon deletion of three amino acids, G86L87I88 Anabaena sp. PCC 7120 ?
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 ?

Synonyms

Synonyms Comment Organism
LexA
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 Anabaena sp.

Expression

Organism Comment Expression
Anabaena sp. exposure to SOS-response inducing stresses, such as UV-B and mitomycin C neither affects the expression of LexA in Anabaena nor induces cleavage of LexA in either Anabaena 7120 or Escherichia coli overexpressing Anabaena LexA protein additional information