Cloned (Comment) | Organism |
---|---|
When there is no DNA damage, the LexA repressors ensure that both recA and lexA are expressed at low basal levels. Before and after DNA damage the promoter activity of recA is low, yet it exhibits some fluctuations. These fluctuations are due to the low copy number of LexA, which is an auto-repressor. In case that the DNA damage persists, the negative regulation acting on both recA and lexA is eventually removed, and the promoter activity of both genes increases, genetic regulation mechanism, overview | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RecA | when RecA is bound to the ssDNA, it becomes an active catalyst for the cleavage of the transcriptional repressor LexA, lowering the level of LexA and relieving the repression of the genes required for the damage repair, including its own transcription and that of lexA | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
LexA | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | LexA transcriptionally represses recA, LexA also functions as an auto-repressor. It is involved in the repair mechanism called the SOS response as a gene regulator, expression dynamics of various genes in the SOS system, overview | Escherichia coli |