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Literature summary for 3.4.21.88 extracted from
- Vibrio cholerae LexA coordinates CTX prophage gene expression (2009), J. Bacteriol., 191, 6788-6795.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of strain BW27784 sulA6209 lexA71, that lacks LexA activity | Vibrio cholerae serotype O1 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Vibrio cholerae serotype O1 | Vibrio cholerae LexA coordinates CTX prophage gene expression, overview. CTXPhi genes require for virion production initiate transcription from the strong PA promoter, which is dually repressed in lysogens by the phage-encoded repressor RstR and the host-encoded SOS repressor LexA. RstR both positively and negatively autoregulates its own expression from this promoter. LexA is absolutely required for RstR-mediated activation of PR transcription. Mechanisms, detailed overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vibrio cholerae serotype O1 | - |
strain HK386 and modified lysogen strain HK138 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Vibrio cholerae LexA coordinates CTX prophage gene expression, overview. CTXPhi genes require for virion production initiate transcription from the strong PA promoter, which is dually repressed in lysogens by the phage-encoded repressor RstR and the host-encoded SOS repressor LexA. RstR both positively and negatively autoregulates its own expression from this promoter. LexA is absolutely required for RstR-mediated activation of PR transcription. Mechanisms, detailed overview | Vibrio cholerae serotype O1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LexA | - |
Vibrio cholerae serotype O1 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Vibrio cholerae LexA coordinates CTX prophage gene expression, overview. CTXPhi genes require for virion production initiate transcription from the strong PA promoter, which is dually repressed in lysogens by the phage-encoded repressor RstR and the host-encoded SOS repressor LexA. RstR both positively and negatively autoregulates its own expression from this promoter. LexA is absolutely required for RstR-mediated activation of PR transcription. Mechanisms, detailed overview | Vibrio cholerae serotype O1 |
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