Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin III | - |
Tachypleus sp. | |
benzamidine | above 20 mM | Tachypleus sp. | |
DFP | - |
Tachypleus sp. | |
leupeptin | above 0.2 mM | Tachypleus sp. | |
LICI-1 | the serpin specifically inhibits factor Cbar | Tachypleus sp. | |
additional information | no inhibition by alpha2-plasmin inhibitor | Tachypleus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Limulus clotting factor B | Tachypleus sp. | active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insoluble coagulin gel | Limulus clotting factor Bbar | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tachypleus sp. | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the proenzyme Limulus coagulation factor C is autocatalytically converted to its active form, factor Cbar | Tachypleus sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Limulus clotting factor B | active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insoluble coagulin gel | Tachypleus sp. | Limulus clotting factor Bbar | - |
? | |
Limulus clotting factor B | active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insiluble coagulin gel | Tachypleus sp. | Limulus clotting factor Bbar | - |
? |