Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of GzmA-/- knockout mice, backcrossed into the C57BL/6 background more than 10 times | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P11032 | - |
- |
Mus musculus C57BL/6 | P11032 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | GZMA is expressed in lungs from wild-type and Mycobacterium tuberculosis-infected mice | Mus musculus | - |
additional information | most of the GZMA-positive cells (over 95%) in non-infected mice are positive for the NK1.1 surface marker with a small proportion of CD8+ and CD4+ T cells, indicating that in the absence of infection GZMA expression in lungs is mainly restricted to natural killer (NK) cells. Conversely, four weeks post-infection, percentage of NK1.1-positive GZMA-expressing cells decreases to 80%, due to the substantial increase observed in the percentage of GZMA-positive CD8+ and CD4+ T cells, (15% and 5%, respectively). In concurrence with these observations, both frequency and absolute number of CD4+ and CD8+ GZMA-expressing cells dramatically increase in lungs upon infection. Tuberculosis infection also leads to an increase in the number of GZMA-expressing NK cells | Mus musculus | - |
natural killer cell | - |
Mus musculus | - |
neutrophil | - |
Mus musculus | - |
T-lymphocyte | CD8+ and CD4+ cells | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Gzma | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | even though granzyme A is expressed by cytotoxic cells from mouse lungs during pulmonary infection, its deficiency in knockout mice does not have an effect in the control of Mycobacterium tuberculosis infection | Mus musculus |
physiological function | granzyme A is expressed in mouse lungs during Mycobacterium tuberculosis strain H37Rv infection but does not contribute to protection in vivo. Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis | Mus musculus |