Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.78 extracted from

  • van den Boogaard, F.E.; van Gisbergen, K.P.; Vernooy, J.H.; Medema, J.P.; Roelofs, J.J.; van Zoelen, M.A.; Endeman, H.; Biesma, D.H.; Boon, L.; Vant Veer, C.; de Vos, A.F.; van der Poll, T.
    Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia (2016), Am. J. Physiol. Lung Cell Mol. Physiol., 311, L507-L516 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P12544
-
-
Mus musculus P11032
-
-
Mus musculus C57BL/6 P11032
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage fluid BALF Mus musculus
-
bronchoalveolar lavage fluid BALF, from community-acquired pneumonia (CAP) patients from the Streptococcus pneumoniae serotype 3-infected and contralateral uninfected side and in lung tissue slides from CAP patients and controls. In CAP patients, GzmA levels are increased in BALF obtained from the infected lung, expression analysis, overview Homo sapiens
-
culture condition:CD8+ cell constitutive expression of granzyme A Mus musculus
-
culture condition:CD8+ cell constitutive expression of granzyme A Homo sapiens
-
lung
-
Mus musculus
-
lung human lungs show constitutive GzmA expression by both parenchymal and nonparenchymal cells Homo sapiens
-
additional information granzyme A is produced by a variety of cell types involved in the immune response Mus musculus
-
additional information granzyme A is produced by a variety of cell types involved in the immune response Homo sapiens
-
natural killer cell constitutive expression of granzyme A Mus musculus
-
natural killer cell constitutive expression of granzyme A Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Gzma
-
Mus musculus
Gzma
-
Homo sapiens

General Information

General Information Comment Organism
malfunction pneumonia is induced in wild-type and GzmA-deficient (GzmA-/-) mice by intranasal inoculation of Streptococcus pneumoniae. In separate experiments, wild-type and GzmA-/- mice are treated with natural killer (NK) cell depleting antibodies. Upon infection, GzmA-/- mice show a better survival and lower bacterial counts in bronchoalveolar lavage fluid (BALF) and distant body sites compared to the wild-type mice. Although NK cells show strong GzmA expression, NK cell depletion does not influence bacterial loads in either wild-type or GzmA-/- mice. GzmA deficiency has little impact on lung pathology during late stage pneumococcal pneumonia Mus musculus
physiological function granzyme A contributes to the early inflammatory response in the lung. Granzyme A (GzmA) impairs host defense during Streptococcus pneumoniae pneumonia, role of GzmA on the host response during pneumococcal pneumonia, overview Homo sapiens
physiological function granzyme A contributes to the early inflammatory response in the lung. Granzyme A (GzmA) plays an unfavorable role in host defense during pneumococcal pneumonia by a mechanism that does not depend on natural killer cells. GzmA enhances bacterial dissemination and mortality in pneumococcal pneumonia Mus musculus