Literature summary for 3.4.21.78 extracted from

Myoumoto, A.; Nakatani, K.; Koshimizu, T.; Matsubara, H.; Adachi, S.; Tsujimoto, G.
Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy (2007), J. Hum. Genet., 52, 328-333.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	glucocorticoid treatment markedly enhances granzyme A expression in glucocorticoid-sensitive but not in glucocorticoid-resistant cell lines	Homo sapiens

Application

Application	Comment	Organism
medicine	investigation of glucocorticoid-induced expression of granzyme A as a potential early biomarker for personalized therapy of acute lymphoblastic leukemia patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P12544	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
acute lymphoblastic leukemia cell line	acute lymphoblastic leukemia-derived cell line 697 used as a positive control, granzyme A mediated glucocorticoid-induced apoptosis shown	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	glucocorticoid sensitivity among cell lines derived from acute lymphoblastic leukemia patients analyzed, correlation between glucocorticoid-induced apoptosis and glucocorticoid-induced mRNA expression of granzyme A shown	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Gzma	-	Homo sapiens

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Release 2023.1 (January 2023)