Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Alpha1-proteinase inhibitor | - |
Homo sapiens | |
alpha2-Macroglobulin | - |
Homo sapiens | |
alpha2-Macroglobulin | - |
Mus musculus | |
antithrombin III | - |
Homo sapiens | |
antithrombin III | - |
Mus musculus | |
Aprotinin | - |
Homo sapiens | |
Aprotinin | - |
Mus musculus | |
benzamidine | - |
Homo sapiens | |
benzamidine | - |
Mus musculus | |
C1 esterase inhibitor | - |
Mus musculus | |
D-Pro-Phe-Arg-CH2Cl | - |
Mus musculus | |
diisopropyl fluorophosphate | - |
Homo sapiens | |
diisopropyl fluorophosphate | - |
Mus musculus | |
leupeptin | - |
Homo sapiens | |
leupeptin | - |
Mus musculus | |
phenylmethanesulfonyl fluoride | - |
Homo sapiens | |
phenylmethanesulfonyl fluoride | - |
Mus musculus | |
Protease nexin-1 | - |
Mus musculus | |
Soybean trypsin inhibitor | - |
Homo sapiens | |
Soybean trypsin inhibitor | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | of effector cells | Mus musculus | 5737 | - |
cytoplasm | of effector cells | Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | ? | - |
? | |
additional information | Homo sapiens | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | enriched cytoplasmic granules | Mus musculus | - |
additional information | enriched cytoplasmic granules | Homo sapiens | - |
T-lymphocyte | cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes | Mus musculus | - |
T-lymphocyte | cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Mus musculus | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
D-Pro-Phe-Arg 4-nitroanilide + H2O | - |
Mus musculus | D-Pro-Phe-Arg + 4-nitroaniline | - |
? | |
Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | Mus musculus | ? | - |
? | |
additional information | overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection | Homo sapiens | ? | - |
? | |
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Mus musculus | ? | - |
? | |
Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively | Mus musculus |
dimer | enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | D-Pro-Phe-Arg 4-nitroanilide, mouse enzyme | Mus musculus |
8 | - |
Gly-Pro-Arg 4-methylcoumarin 7-amide, human enzyme | Homo sapiens |
11 | - |
tosyl-Gly-Pro-Arg 4-nitroanilide, human enzyme | Homo sapiens |