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Literature summary for 3.4.21.77 extracted from

  • Misra, U.K.; Payne, S.; Pizzo, S.V.
    Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen (2011), J. Biol. Chem., 286, 1248-1259.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PSA may be involved in a signal transduction-dependent feedback loop, whereby it promotes a more aggressive behavior by human prostate cancer cells. Ligation of prostate cancer cell surface protein GRP78 by its natural ligand, activated alpha2-macroglobulin, results in a 2-3-fold upregulation in the synthesis of PSA. The PSA is secreted into the medium as an active proteinase, where it binds to native alpha2-macroglobulin. The resultant alpha2-macroglobulin-PSA complexes bind to GRP78, causing a 1.5-2fold increase in the activation of MEK1/2, ERK1/2, S6K, and Akt, which is coupled with a 2-3-fold increase in DNA and protein synthesis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
1-LN cell prostate cancer cell, expressing GRP78 on its surface Homo sapiens
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DU-145 cell prostate cancer cell, expressing GRP78 on its surface Homo sapiens
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PC-3 cell prostate cancer cell, no expression of GRP78 on the surface Homo sapiens
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General Information

General Information Comment Organism
malfunction ligation of prostate cancer cell surface protein GRP78 by its natural ligand, activated alpha2-macroglobulin, results in a 2-3-fold upregulation in the synthesis of PSA. The PSA is secreted into the medium as an active proteinase, where it binds to native alpha2-macroglobulin. The resultant alpha2-macroglobulin-PSA complexes bind to GRP78, causing a 1.5-2fold increase in the activation of MEK1/2, ERK1/2, S6K, and Akt, which is coupled with a 2-3-fold increase in DNA and protein synthesis Homo sapiens