Literature summary for 3.4.21.77 extracted from

Ide, H.; Tokiwa, S.; Sakamaki, K.; Nishio, K.; Isotani, S.; Muto, S.; Hama, T.; Masuda, H.; Horie, S.
Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen (2010), Prostate, 70, 1127-1133.

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Application

Application	Comment	Organism
medicine	effects of isoflavones and curcumin on PSA production in prostate cells, particularly in combination, may have therapeutic advantages in patients with high PSA level who has negative prostate biopsies. Isoflavones and curcumin may improve the asymptomatic inflammation in prostates with high serum PSA levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP cell	-	Homo sapiens	-
serum	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
prostate-specific antigen	-	Homo sapiens
PSA	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	treatment of LNCaP cells with 10 microg/ml soy isoflavones alone causes 40% inhibition of PSA secretion to the supernatant compared to control, whereas treatment of the cells with 20 micromol curcumin causes 20% inhibition. Combined treatment of curcumin and soy isoflavones enhances inhibition of PSA production and expression of androgen receptor in LNCaP cells: treatment with 10 microg/ml isoflavones combined with 20 micromol curcumin causes almost complete inhibition of PSA production. In a randomized, placebo-controlled clinical trial, a combined treatment of soy isoflavones and curcumin decreases serum PSA in those subjects whose baseline PSA is more than 10 ng/ml	down

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Release 2023.1 (January 2023)