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Literature summary for 3.4.21.77 extracted from

  • Slupianek, A.; Yerrum, S.; Safadi, F.F.; Monroy, M.A.
    The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cells (2010), J. Cell. Physiol., 224, 369-375.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
22Rv1 cell
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Homo sapiens
-
LNCaP cell
-
Homo sapiens
-
PC-3 cell
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
prostate specific antigen
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Homo sapiens
PSA
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens shRNA mediated knockdown of SNF2-related CBP activator protein results in decreased H2A.Z binding at the enhancer region of the PSA promoter and decreased expression of PSA in prostate cancer cells down
Homo sapiens SNF2-related CBP activator protein is a physiologically relevant mediator of PSA expression: it enhances the transcriptional activity of PSA and this activation is further enhanced in the presence of dihydrotestosterone. SNF2-related CBP activator protein activates hormone-dependent transcription of the androgen responsive, PSA-Luciferase reporter gene in prostate cells up