Application | Comment | Organism |
---|---|---|
medicine | decreases in prostate volume over time and the resultant change in prostate-specific antigen performance characteristics may have contributed a bias toward the detection of high-grade disease in the finasteride arm of the Prostate Cancer Prevention Trial. Performance of prostate specific antigen for the detection of any cancer and high-grade cancer is affected by prostate size: prostate-specific antigen performance is significantly better in men with smaller prostates for both the detection of low-grade and high-grade disease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
prostate-specific antigen | - |
Homo sapiens |
PSA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | prostate-specific antigen levels between various diagnoses of cancer and size strata have minimal variation. In patients with prostate volumes greater than 50 cm3, prostate-specific antigen density levels have minimal variation between any histologic diagnosis, benign or malignant. The median prostate-specific antigen density levels in men without cancer in small or intermediate prostates (greater than 30 cm3 and 30-50 cm3, respectively) are similar. The prostate-specific antigen density in patients with cancer (low or high grade) is significantly higher in smaller prostates compared with intermediate-sized prostates | Homo sapiens |