Literature summary for 3.4.21.77 extracted from

Jeong, S.; Han, S.R.; Lee, Y.J.; Lee, S.W.
Selection of RNA aptamers specific to active prostate-specific antigen (2010), Biotechnol. Lett., 32, 379-385.

Search for more literature for 3.4.21.77

Application

Application	Comment	Organism
analysis	development and employment of counter-SELEX (systematic evolution of ligands by exponential enrichment) procedures to identify specific RNA aptamers against the purified active PSA, wich is not only a specific marker but also a target molecule for diagnosis and therapy of prostate cancer. The aptamers have a specific binding activity against the active PSA, but not for GST or proPSA	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant proteins of proPSA and active PSA cloned into pGEX4T-1 expression vector that produces recombinant proteins with N-terminal GST tags. The proteins expressed in Escherichia coli BL21(DE3)	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by gel filtration	Homo sapiens

Synonyms

Synonyms	Comment	Organism
prostate-specific antigen	-	Homo sapiens
PSA	-	Homo sapiens

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Release 2023.1 (January 2023)