Literature summary for 3.4.21.76 extracted from

Kim, Y.C.; Shin, J.E.; Lee, S.H.; Chung, W.J.; Lee, Y.S.; Choi, B.K.; Choi, Y.
Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils (2011), Mol. Immunol., 48, 1966-1974.

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Application

Application	Comment	Organism
medicine	affinity chromatography of neutrophil lysates using epoxy beads coated with Streptococcus sanguinis reveals involvement of PR3 in phagocytosis of Streptococcus sanguinis. Enzymatic cleavage of the glycosylphosphatidylinositol linker of NB1, a co-receptor for membrane-bound PR3, significantly reduces the phagocytosis. The neutralization of membrane-bound PR3 with antibody reduces both binding and phagocytosis of Streptococcus sanguinis. Protease activity is required for phagocytosis, and protease-activated receptor PAR2 is involved in signal transmission from PR3 during this process	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neutrophilic myelocyte	-	Homo sapiens	-

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Release 2023.1 (January 2023)