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Literature summary for 3.4.21.76 extracted from

  • Kaellquist, L.; Rosen, H.; Nordenfelt, P.; Calafat, J.; Janssen, H.; Persson, A.M.; Hansson, M.; Olsson, I.
    Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells (2010), Exp. Cell Res., 316, 3182-3196.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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General Information

General Information Comment Organism
metabolism pro-PR3 interacts with CD63 upon heterologous co-expression in COS cells but endogenous interaction is not detected although cell surface proPR3 and CD63 are co-endocytosed in myelomonocytic cells. Cell surface pro-PR3 turns over more rapidly than cell surface CD63 consistent with processing/degradation of the pro-protease but recycling of CD63. Colocalization of proPR3 and CD63 with clathrin and Rab 7 suggests trafficking through coated vesicles and late endosomes. Blocking the C-terminus of pro-PR3 by creating a fusion with FK506 binding protein does not inhibit endosomal re-uptake of proPR3 Homo sapiens