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Literature summary for 3.4.21.76 extracted from

  • Abdgawad, M.; Gunnarsson, L.; Bengtsson, A.A.; Geborek, P.; Nilsson, L.; Segelmark, M.; Hellmark, T.
    Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression (2010), Clin. Exp. Immunol., 161, 89-97.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in all individuals tested, neutrophils are either double-positive or double-negative for mPR3 and CD177. The proportion of double-positive neutrophils is increased significantly in anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis and systemic lupus erythematosus patients. The proportion of mPR3+/CD177+ cells is not correlated to general inflammation, renal function, age, sex, drug treatment and levels of circulating PR3. The increased membrane expression of PR3 found in anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis is not linked directly to circulating PR3 or PR3 gene transcription, but is dependent upon CD177 expression and correlated with the transcription of the CD177 gene Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pro-PR3 is found to constitute 10% of circulating PR3 but none of the membrane-PR3 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neutrophilic myelocyte
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Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens in patients with anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis, increased mRNA levels of both PR3 and CD177 are found, which do not correlate with the proportion of double-positive cells up