Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.76 extracted from

  • Piesche, M.; Hildebrandt, Y.; Chapuy, B.; Wulf, G.G.; Truemper, L.; Schroers, R.
    Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3 (2009), Vaccine, 27, 4718-4723.
    View publication on PubMed
Search for more literature for 3.4.21.76

Activating Compound

Activating Compound Comment Organism Structure
additional information PRTN3235-specific T-cells can be stimulated from the blood of healthy individuals with multiple HLA-DR-genotypes Homo sapiens

Application

Application Comment Organism
medicine PRTN3 is a promising antigen for immunotherapy of myeloid leukemia Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant PRTN3 protein with an amino-terminal histidine tag produced in SF-9 insect cells by use of a baculovirus expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information peptide-specific T-cell responses, exemplary for PRTN358 and PRTN3235, can be inhibited by anti-HLA-DR antibodies, but not by an anti-HLAABC antibody Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by nickel-chelating affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
additional information PRTN3-negative HEK293 and PM-1 tumor cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
proteinase 3
-
 Homo sapiens
PRTN3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function PRTN3-specific CD4+ T-cells precursors are part of normal human T-cell repertoires. T-cell precursors specific for various PRTN3 epitopes can be activated when properly stimulated. T-cell clones proliferate in response to peptides PRTN358 (GTLIHPSFVLTAAHALRDI), PRTN3216 (IDSFVIWGAATRLFPDFF), PRTN3235 (RVALYVDWIRSTLRR), and PRTN3241 (DWIRSTLRRVEAKGRP). T-cell clones specific for these four PRTN3 peptides strongly respond to autologous peripheral blood mononuclear cells in the presence of corresponding peptides. Only PRTN3235 is recognized by CD4+ T-cells as a naturally processed HLAclass-II-epitope. PRTN3235-specific CD4+ T-cells do not proliferate vigorously to stimulation with PRTN3-positive leukemia cell. PRTN3235 is able to induce T-cell responses in individuals with diverse DR genotypes Homo sapiens