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Literature summary for 3.4.21.76 extracted from
- Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3 (2009), Clin. Exp. Immunol., 156, 336-343.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolar macrophage | increased PR-3 on the alveolar macrophage surface in usual interstitial pneumonia relative to healthy controls and sarcoidosis subjects | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| tumour necrosis factor-alpha + H2O | PR-3-mediated cleavage of tumour necrosis factor-alpha in usual interstitial pneumonia, which may have implications for future therapeutic targeting of tumour necrosis factor-alpha converting enzyme (TACE) | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PR-3 | - |
Homo sapiens |
| Proteinase-3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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