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Literature summary for 3.4.21.76 extracted from
- The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A (2007), Proteins, 68, 738-748.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Pichia pastoris | Candida albicans |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, in the presence of Zn2+, to 1.9 and 2.2 A resolution. Inhibitor binding causes active site closure by the movement of a flap segment. Sap3 consists of the S2' binding site becoming channelshaped subsequent to the turn of the loop with residues 129135 | Candida albicans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by anion-exchange chromatography and gel filtration | Candida albicans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Candida albicans | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SAP3 | - |
Candida albicans |
| secreted aspartic proteinase 3 | - |
Candida albicans |
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Release 2023.1 (January 2023)
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