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Literature summary for 3.4.21.76 extracted from
- Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils (2007), J. Leukoc. Biol., 81, 458-464.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytochalasin B | PR3 and CD177 are increased in parallel. Stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive | Homo sapiens |  |
| fMLP | PR3 and CD177 are increased in parallel. Causes a moderate increase. stimulating cells with cytochalasin B in combination with fML, PmPR3- and CD177-negative cells become positive | Homo sapiens | |
| PMA | PR3 and CD177 are increased in parallel. Increases 4.9fold. mPR3- and CD177-negative cells become positive | Homo sapiens | |
| TNF-alpha | PR3 and CD177 are increased in parallel. Causes a moderate increase | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PR3- and CD177-expressing neutrophils constitute a subpopulation of neutrophils with an unknown role in the innate immune system, which may play an important role in diseases such as Wegeners granulomatosis and polycythemia vera | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | strong correlation between PR3 and CD177 surface expression | Homo sapiens | 9986 | - |
| plasma membrane | PR3 and CD177 exhibit a dynamic plasma membrane expression with rapid internalization and re-expression | Homo sapiens | 5886 | - |
| secondary granule | - |
Homo sapiens | - |
- |
| secretory vesicle | - |
Homo sapiens | 99503 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | PR3 and CD177 are coexpressed on a subset of neutrophils | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PR3 | - |
Homo sapiens |
| proteinase 3 | - |
Homo sapiens |
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