Application | Comment | Organism |
---|---|---|
drug development | design of inhibitors aimed at neutralizing the cleavage activity of PR3 toward endogenous annexin 1 and hence suitable for development as novel anti-inflammatory therapeutics | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of active PR3 and its inactive mutant in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S203A | inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PMSF | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | endogenous annexin 1 and PR3 localization in resting and stimulated blood neutrophils | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
annexin 1 + H2O | proteinase 3 is the main enzyme responsible for cleavage in the N terminus region of the protein | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Homo sapiens |