Application | Comment | Organism |
---|---|---|
medicine | involved in autoimmune small vessel vasculitides, e. g. Wegener´s granulomatosis. PR3 is the main target autoatigen of antineutrophilic cytoplasmic antibodies (ANCA). Structure(charge)-based binding interactions between PR3-ANCA and conformational epitopes of PR3. Binding of PR3 to physiological molecules as well as to autoantibodies may induce and promote proinflammatory responses | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | physiologic inhibitor of PR3 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
azurophil granule | - |
Homo sapiens | 42582 | - |
cell surface | - |
Homo sapiens | 9986 | - |
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
polymorphonuclear leukocyte | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IL-32 + H2O | - |
Homo sapiens | ? | - |
? | |
protease-activated receptor-2 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PR3 | - |
Homo sapiens |
proteinase 3 | - |
Homo sapiens |