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Literature summary for 3.4.21.76 extracted from
- Proteinase 3 sidesteps caspases and cleaves p21 Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis (2004), Kidney Int., 65, 75-84.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | irreversible inhibition | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P24158 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HUVEC cell | - |
Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| BID + H2O | 37°C, Bid = BH3 interacting domain death agonist | Homo sapiens | ? | - |
? | |
| nuclear factor-kappaB + H2O | - |
Homo sapiens | ? | - |
? | |
| p21 + H2O | 37°C, cleavage occurs between Thr80 and Gly81 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PR3 | - |
Homo sapiens |
| proteinase 3 | - |
Homo sapiens |
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