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Literature summary for 3.4.21.76 extracted from

  • Nobar, S.M.; Zani, M.L.; Boudier, C.; Moreau, T.; Bieth, J.G.
    Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 (2005), FEBS J., 272, 5883-5893.
    View publication on PubMed
Search for more literature for 3.4.21.76

Inhibitors

Inhibitors Comment Organism Structure
elafin 55% inhibition, oxidized with N-chlorosuccinimide: 10% inhibition Homo sapiens
trappin 80% inhibition, oxidized with N-chlorosuccinimide: 19% inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P24158
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-p-nitroanilide + H2O pH 7.4, 150 mM NaCl Homo sapiens ?
-
 ?
methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester + H2O pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
proteinase 3
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000012
-
 elafin methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens
0.00000018
-
 trappin methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens
0.000025
-
 elafin, oxidized with myeloperoxidase methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens
0.000029
-
 elafin, oxidized with N-chlorosuccinimide methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens
0.000035
-
 trappin, oxidized with myeloperoxidase methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens
0.00005
-
 trappin, oxidized with N-chlorosuccinimide methoxysuccinyl-lysyl-(2-picolinoyl)-Ala-Pro-Val-thiobenzylester as substrate, pH 7.4, 150 mM NaCl, 3 mM 4,4’-dithiodipyridine Homo sapiens