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Literature summary for 3.4.21.76 extracted from

  • Korkmaz, B.; Attucci, S.; Moreau, T.; Godat, E.; Juliano, L.; Gauthier, F.
    Design and use of highly specific substrates of neutrophil elastase and proteinase 3 (2004), Am. J. Respir. Cell Mol. Biol., 30, 801-807.
    View publication on PubMed
Search for more literature for 3.4.21.76

Inhibitors

Inhibitors Comment Organism Structure
alpha1-protease inhibitor 50-70% inhibition Homo sapiens
MeO-Suc-AAPA-chloromethyl ketone poor inhibition Homo sapiens
additional information low molecular weight serine protease inhibitors, but only partially by inhibitors of larger molecular weight such as alpha1-protease inhibitor Homo sapiens
PMSF
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0065
-
 Abz-VADCADY(NO2) 37°C, pH 7.4, 150 mM NaCl Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P24158
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-APEEIMDDQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 2.5/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMDQQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 2/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMDRQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 14.6/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMDRY-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = lower than 1/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMDRYQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 3.2/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMDYQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 2.6/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMPRQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = lower than 1/mM/s Homo sapiens ?
-
 ?
Abz-APEEIMRRQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = lower than 1/mM/s Homo sapiens ?
-
 ?
Abz-VADCADQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 614/mM/s Homo sapiens ?
-
 ?
Abz-VADCADRY(NO2) + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 651/mM/s Homo sapiens ?
-
 ?
Abz-VADCADY(NO2) + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 630/mM/s Homo sapiens ?
-
 ?
Abz-VADCAPY(NO2) + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = lower than 1/mM/s Homo sapiens ?
-
 ?
Abz-VADCAQ-ethylene diamine 2,4 dinitrophenyl + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 292/mM/s Homo sapiens ?
-
 ?
Abz-VADCARY(NO2) + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 3.8/mM/s Homo sapiens ?
-
 ?
Abz-VADCAY(NO2) + H2O 37°C, pH 7.4, 150 mM NaCl, kcat/KM = 10.9/mM/s Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PR3
-
 Homo sapiens
proteinase 3
-
 Homo sapiens