Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-brain-derived neurotrophic factor + H2O | Rattus norvegicus | - |
mature brain-derived neurotrophic factor + ? | - |
? | |
pro-brain-derived neurotrophic factor + H2O | Rattus norvegicus Sprague Dawley | - |
mature brain-derived neurotrophic factor + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague Dawley | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | primary cortical | Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-brain-derived neurotrophic factor + H2O | - |
Rattus norvegicus | mature brain-derived neurotrophic factor + ? | - |
? | |
pro-brain-derived neurotrophic factor + H2O | - |
Rattus norvegicus Sprague Dawley | mature brain-derived neurotrophic factor + ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | the enzyme is upregulated and cleaves certain substrates during hypoxia in cancer cells. In oxygen-glucose deprivation, expression of the enzyme and of brain-derived neurotrophic factor is upregulated | up |
General Information | Comment | Organism |
---|---|---|
malfunction | furin inhibition reduces brain-derived neurotrophic factor maturation and secretion | Rattus norvegicus |
physiological function | furin is upregulated and cleaves certain substrates during hypoxia in cancer cells, the enzyme mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation. Maturation of brain-derived neurotrophic factor in astrocytes requires furin-mediated endoproteolytic processing of the precursor protein pro-brain-derived neurotrophic factor to brain-derived neurotrophic factor | Rattus norvegicus |