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Literature summary for 3.4.21.75 extracted from

  • Zhou, Z.; Zhang, Q.; Lu, X.; Wang, R.; Wang, H.; Wang, Y.L.; Zhu, C.; Lin, H.Y.; Wang, H.
    The proprotein convertase furin is required for trophoblast syncytialization (2013), Cell Death Dis., 4, e593-e602.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Protein Variants

Protein Variants Comment Organism
additional information furin siRNA efficiently inhibits furin expression, expression of enzyme-specific siRNA in choriocarcinoma cells inhibits cell fusion Homo sapiens
additional information production of lentiviruses carrying shRNA for furin and infection of blastocyststage embryos with the viruses, along with lentiviruses expressing EGFP Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
type 1 IGF receptor + H2O Homo sapiens
-
 mature type I IDF receptor + ?
-
 ?
type 1 IGF receptor pro-form + H2O Mus musculus
-
 mature type I IDF receptor + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09958
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cytotrophoblast primary Homo sapiens
-
placenta
-
 Mus musculus
-
placenta proprotein convertase furin is highly expressed in syncytial trophoblast in the first trimester human placentas, and expression of furin in the syncytiotrophoblast is significantly lower in the placentas from pre-eclamptic patients as compared with their gestational age-matched control placentas Homo sapiens
-
syncytial trophoblast
-
 Mus musculus
-
syncytial trophoblast proprotein convertase furin is highly expressed in syncytial trophoblast in the first trimester human placentas, and expression of furin in the syncytiotrophoblast is significantly lower in the placentas from pre-eclamptic patients as compared with their gestational age-matched control placentas Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
type 1 IGF receptor + H2O
-
 Homo sapiens mature type I IDF receptor + ?
-
 ?
type 1 IGF receptor pro-form + H2O
-
 Mus musculus mature type I IDF receptor + ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens forskolin induces the enzyme expression in choriocarcinoma cells up

General Information

General Information Comment Organism
malfunction furin-specific siRNAs or inhibitors inhibit cell fusion in choriocarcinoma BeWo cells, as well as trophoblast syncytialization in human placental explants Homo sapiens
malfunction placenta-specific knockdown of furin in the mouse leads to severe defects in syncytialization and embryonic lethality, phenotype, overview Mus musculus
physiological function the multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Cytotrophoblast cell fusion and syncytialization are accompanied by furin expression. Processing of type 1 IGF receptor by furin is an essential mechanism for syncytialization. Furin function is required for the development of syncytiotrophoblast structure in the labyrinth layer, as well as for normal embryonic development Mus musculus
physiological function the multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Cytotrophoblast cell fusion and syncytialization are accompanied by furin expression. Processing of type 1 IGF receptor by furin is an essential mechanism for syncytialization. Furin function is required for the development of syncytiotrophoblast structure in the labyrinth layer, as well as for normal embryonic development Homo sapiens