Inhibitors | Comment | Organism | Structure |
---|---|---|---|
decanoyl-RVRR-chloromethyl ketone | - |
Homo sapiens | |
hfurin25-107 | i.e. furin prodomain protein, competitive inhibitor, blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain, overview. Secondary structure of furin prodomain protein, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | furin cleavage sequence is RXXR-/-X, X is not Cys | Homo sapiens | ? | - |
? | |
N-benzyloxycarbonyl-RVRR-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-RVRR + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | secondary structure of furin prodomain protein, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Proprotein convertase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
0.000156 | - |
hfurin25-107 | pH 7.4, 37°C, versus N-benzyloxycarbonyl-RVRR-4-methylcoumarin 7-amide | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain, overview | Homo sapiens |