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Literature summary for 3.4.21.75 extracted from

  • Ito, K.; Kim, K.H.; Lok, A.S.; Tong, S.
    Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme (2009), J. Virol., 83, 3507-3517.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloned into vector pAdTrack-CMV, followed by recombination in Escherichia coli cells with the adenovirus backbone pAdEasy-1, recombinant DNA transfected to HEK-293 cells. Introduction by adenovirus vector in LoVo cells Gallus gallus
human furin cDNA transfected to Huh-7 cells, HepG-2 cells and HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone blocks cleavage of the first and second motifs in human hepatoma cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatitis B e antigen precursor + H2O
-
 Homo sapiens ?
-
 ?
hepatitis B e antigen precursor + H2O furin can cleave the RRDR, RRGR, and RSPR motifs Gallus gallus ?
-
 ?

Synonyms

Synonyms Comment Organism
furin
-
 Homo sapiens