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Literature summary for 3.4.21.75 extracted from

  • Tellier, E.; Negre-Salvayre, A.; Bocquet, B.; Itohara, S.; Hannun, Y.A.; Salvayre, R.; Auge, N.
    Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway (2007), Mol. Cell. Biol., 27, 2997-3007.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Activating Compound

Activating Compound Comment Organism Structure
Tumor necrosis factor alpha
-
 Homo sapiens

Application

Application Comment Organism
medicine pivotal role for furin, MT1-MMP, and MMP2 in tumor necrosis factor alpha-induced sphingolipid signaling. This system may be a possible target to inhibit smooth muscle cell proliferation in vascular diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-PDX inhibitor
-
 Homo sapiens
brefeldin A blocks the tumor necrosis factor alpha-induced activation of furin and subsequent neutral sphingomyelinase activation, without altering the basal level of furin Homo sapiens
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Homo sapiens
monensin blocks the tumor necrosis factor alpha-induced activation of furin and subsequent neutral sphingomyelinase activation, without altering the basal level of furin Homo sapiens
siRNA
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inactive pro-MT1-MMP + H2O
-
 Homo sapiens active MT1-MMP + ?
-
 ?
pyroglutamic acid-Arg-Thr-Lys-Arg-methylcoumaryl-7-amide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
proconvertase
-
 Homo sapiens