Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.75 extracted from

  • Harris, M.; Garcia-Caballero, A.; Stutts, M.J.; Firsov, D.; Rossier, B.C.
    Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: Role of furin-mediated endogenous proteolysis (2008), J. Biol. Chem., 283, 7455-7463.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Protein Variants

Protein Variants Comment Organism
R138A mutation of the furin cleavage site in the gamma subunit, gamma furin site mutation interfers with protein synthesis and/or degradation Xenopus sp.
R205A/R231A mutation of the furin cleavage site in the alpha subunit, eliminates the appearance of the 65-kDa cleavage product at the cell surface Xenopus sp.

Organism

Organism UniProt Comment Textmining
Xenopus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Xenopus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
epithelial Na+ channel + H2O epithelial Na+ channel activation during preferential assembly requires furin-dependent and furin-independent processing. Furin consensus site on the alpha subunit is required for epithelial Na+ channel activation upon assembly into alphabetagamma complexes, beta subunit may play a distinct furin-independent role in activation. No causal relationship between gamma cleavage and epithelial Na+ channel activation upon preferential assembly Xenopus sp. ?
-
 ?