Protein Variants | Comment | Organism |
---|---|---|
R138A | mutation of the furin cleavage site in the gamma subunit, gamma furin site mutation interfers with protein synthesis and/or degradation | Xenopus sp. |
R205A/R231A | mutation of the furin cleavage site in the alpha subunit, eliminates the appearance of the 65-kDa cleavage product at the cell surface | Xenopus sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Xenopus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
epithelial Na+ channel + H2O | epithelial Na+ channel activation during preferential assembly requires furin-dependent and furin-independent processing. Furin consensus site on the alpha subunit is required for epithelial Na+ channel activation upon assembly into alphabetagamma complexes, beta subunit may play a distinct furin-independent role in activation. No causal relationship between gamma cleavage and epithelial Na+ channel activation upon preferential assembly | Xenopus sp. | ? | - |
? |