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Literature summary for 3.4.21.75 extracted from
- Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens (2007), J. Biol. Chem., 282, 20847-20853.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibiting furin-like proprotein convertases protects the host from the distinct furin-dependent infections and lay a foundation for novel, host cell-focused therapies against acute diseases | Mus musculus |
| medicine | inhibiting furin-like proprotein convertases protects the host from the distinct furin-dependent infections and lay a foundation for novel, host cell-focused therapies against acute diseases | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant furin prepared in the S2 Drosophila expression system | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| decanoyl-Arg-Val-Lys-Arg-chloromethylketone | - |
Homo sapiens |  |
| TPQRARRRKKRF | - |
Homo sapiens | |
| TPQRARRRKKRT | - |
Homo sapiens | |
| TPQRARRRKKRW | - |
Homo sapiens | |
| TPQRARRRKKRY | - |
Homo sapiens | |
| TPRARRRKKRG | - |
Homo sapiens | |
| TPRARRRKKRI | - |
Homo sapiens | |
| TPRARRRKKRT | - |
Homo sapiens | |
| TPRARRRKKRT | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57/BL6 mice | - |
| Mus musculus C57BL/6 | - |
C57/BL6 mice | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hemagglutinin + H2O | - |
Homo sapiens | ? | - |
? | |
| PA83 + H2O | - |
Homo sapiens | PA63 + PA20 | - |
? | |
| Pseudomonas exotoxin A + H2O | - |
Mus musculus | ? | - |
? | |
| Pseudomonas exotoxin A + H2O | - |
Homo sapiens | ? | - |
? | |
| Pseudomonas exotoxin A + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
| pyroglutamic acid-Arg-Thr-Lys-Arg-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Proprotein convertase | - |
Mus musculus |
| Proprotein convertase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000023 | - |
TPRARRRKKRT | - |
Homo sapiens | |
| 0.00003 | - |
TPRARRRKKRI | - |
Homo sapiens | |
| 0.000033 | - |
TPQRARRRKKRT | - |
Homo sapiens | |
| 0.000034 | - |
TPQRARRRKKRW | - |
Homo sapiens | |
| 0.000038 | - |
TPQRARRRKKRF | - |
Homo sapiens | |
| 0.000047 | - |
TPQRARRRKKRY | - |
Homo sapiens | |
| 0.000057 | - |
TPRARRRKKRG | - |
Homo sapiens | |
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