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Literature summary for 3.4.21.75 extracted from

  • Lapierre, M.; Siegfried, G.; Scamuffa, N.; Bontemps, Y.; Calvo, F.; Seidah, N.G.; Khatib, A.M.
    Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells malignant phenotypes: role of tissue inhibitors of metalloproteinase-1 (2007), Cancer Res., 67, 9030-9034.
    View publication on PubMed

Application

Application Comment Organism
medicine specific and opposing roles of furin and PACE4 in the regulation of MMP-9/TIMP-1 mediated cell motility and invasion. Furin prosegment inhibits cell migration and invasion as well as MMP-9 activity without affecting TIMP-1. It prevents adequate repair of scratch wounds Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
MDA-MB-231 breast cancer cells stably transfected with a vector containing furin prosegment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha1-antitrypsin in cells overexpressing alpha1-antitrypsin, mRNA level of furin is reduced Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Proprotein convertase
-
Homo sapiens