Application | Comment | Organism |
---|---|---|
medicine | specific and opposing roles of furin and PACE4 in the regulation of MMP-9/TIMP-1 mediated cell motility and invasion. Furin prosegment inhibits cell migration and invasion as well as MMP-9 activity without affecting TIMP-1. It prevents adequate repair of scratch wounds | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
MDA-MB-231 breast cancer cells stably transfected with a vector containing furin prosegment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-antitrypsin | in cells overexpressing alpha1-antitrypsin, mRNA level of furin is reduced | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Proprotein convertase | - |
Homo sapiens |