Cloned (Comment) | Organism |
---|---|
stably transfected LoVo cells expressing either furin (LoVo/fur) or the vector alone (LoVo/neo) | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | LoVo/neo cells lacking functional furin are unable to activate both wild type Shiga toxin and mutant Shiga-2D toxin | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEp-2 cell | - |
Homo sapiens | - |
LoVo cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | is not able to cleave mutant Shiga-2D toxin | Mus musculus | ? | - |
? | |
additional information | is not able to cleave mutant Shiga-2D toxin | Homo sapiens | ? | - |
? | |
Shiga toxin + H2O | not only the sequence known to be a minimal furin-recognition site, but also the structure around this site are important for furin processing of Shiga toxin and for rapid intoxication | Mus musculus | ? | - |
? | |
Shiga toxin + H2O | not only the sequence known to be a minimal furin-recognition site, but also the structure around this site are important for furin processing of Shiga toxin and for rapid intoxication | Homo sapiens | ? | - |
? |