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Literature summary for 3.4.21.75 extracted from

  • Anders, L.; Mertins, P.; Lammich, S.; Murgia, M.; Hartmann, D.; Saftig, P.; Haass, C.; Ullrich, A.
    Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenins transcriptional activity (2006), Mol. Cell. Biol., 26, 3917-3934.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.75

Cloned(Commentary)

Cloned (Comment) Organism
LoVo cells stably expressing furin. Furin cleavage-site mutant (LNTR) transfected into COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information furin cleavage-site mutant, neither trifluoperazine-induced nor basal shedding causes P-stalk accumulation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Homo sapiens
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
fibroblast
-
 Mus musculus
-
additional information absent from LoVo cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RPTPkappa + H2O
-
 Mus musculus ?
-
 ?
RPTPkappa + H2O furin is required for S1 processing of RPTPkappa in the secretory pathway. Purified furin cleaves RPTPkappa within the membrane-proximal fibronectin type III domain at the sequence RTKR Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
subtilisin-like protein convertase
-
 Mus musculus
subtilisin-like protein convertase
-
 Homo sapiens