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Literature summary for 3.4.21.75 extracted from
- Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone (2004), Endocrinology, 145, 1961-1971.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mouse pro-growth hormone-releasing hormone + H2O | Mus musculus | production of mature growth hormone-releasing hormone from pro-growth hormone-releasing hormone is a stepwise process mediated predomionantly by furin at the N-terminal cleavage site followed by PC1/3 at the C terminus | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
recombinant | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mouse pro-growth hormone-releasing hormone + H2O | production of mature growth hormone-releasing hormone from pro-growth hormone-releasing hormone is a stepwise process mediated predomionantly by furin at the N-terminal cleavage site followed by PC1/3 at the C terminus | Mus musculus | ? | - |
? | |
| mouse pro-growth hormone-releasing hormone + H2O | furin is the most efficient convertase in cleaving the N-terminal RXXR/RXRR site | Mus musculus | ? | - |
? | |
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