Literature summary for 3.4.21.75 extracted from

Brennan, S.O.; Nakayama, K.
Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase (1994), FEBS Lett., 338, 147-151.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha1-antitrypsin	not inhibited by normal antitrypsin M	Mus musculus
antithrombin	not	Mus musculus
antithrombin/heparin	not: antithrombin alone	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Protein precursor + H2O	rapid cleavage of the-Arg-Arg-Asp-site, no significant cleavage of natural unprocessed variants with cleavage site sequences of-Arg-Arg-Val-, His-Arg-Asp- or Cys-Arg-Asp	Mus musculus	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	6	proalbumin	Mus musculus

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
5	-	30°C, 2 h, 50 mM MES buffer, 10% loss of activity	Mus musculus
7	-	30°C, 2 h, 50 mM MES buffer, about 90% loss of activity	Mus musculus

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Release 2023.1 (January 2023)